TOKYO-- July 12, 2021 -- Cartilage of the knee joint, when severely damaged by age related wear and tear or injury or osteoarthritis, which is removed and usually discarded, during joint replacement surgery, now could be rejuvenated, becoming a potential source of cells for cell therapy through a disruptive technology that reverses aging, confirmed by Senescence associated ß-Galactosidase, p16 and p21, markers, published in Scientific Reports (www.nature.com/articles/s41598-021-93607-9), a Nature journal. A conversation between (Late) Prof. Masatoshi Koshiba, (Nobel Laureate, 2002) and Dr. Masahiro Katoh on whether his aging joints could be rejuvenated, inspired orthopedician Dr Shojiro Katoh to develop a path breaking EELS-TALC technique (Enriched with Essentials and Lapped in Scaffold, Transplant-suitable Autologous Leveraged Chondrocytes), making this accomplishment.

Aging of human body, its organs, tissues and cells is irreversible and in the lab environments, aging is much faster than inside the body. However, EELS-TALC technology has disrupted this conventional belief by making tissues younger, through tissue engineering in a chemically synthesized polymer scaffold, under physical maneuver of orbital shaking in the lab, without genetic manipulation or animal derived products, thus paving way to solutions that, when similar environment is made available inside the body, such reversal of aging might be possible.

EELS TALC cultured chondrocytes have all ideal characteristics, worth recommending as the most suitable in ACI and MACI treatments: